A deadly pathogen is unleashed and unknowingly carried to Dana Overbeck's 30th birthday party, where her estranged father, Rufus, is coming to make amends.

A scheming con artist poses as the innocent babysitter "Amber" to steal from a wealthy occult enthusiast with a reclusive son, Kevin. Her crew arrives to clean out the house just as Kevin stumbles upon a prized artifact and unwittingly summons a trio of witches known as The Three Mothers.